There is a narrow yet optimal window of opportunity to direct healthy immune system function and moderate inflammation when immune system development is first being established. And with autoimmune disease on the rise, leveraging this critical period is paramount to improving long-term health. However, doing so requires the proper microbial partners to influence development.
Our discovery of B. infantis EVC001—a bacterial strain thought to have disappeared from developed countries—proves to be the microbial partner nature intended.
While B. infantis has evolved over time to uniquely pair with human milk, only EVC001 is clinically proven to have all the genes required to metabolize the HMOs in human milk, and more importantly, it contains the functional genes necessary to produce metabolites that positively influence healthy immune system development and moderate inflammation when introduced during this short but critical time.
By enabling the delivery of B. infantis EVC001 from birth, we maximize that small but crucial window of opportunity. Influencing the development of healthier immune systems and beginning to set the trajectory of human health, one baby at a time.
Immune disfunction is linked to future risk for allergic and autoimmune conditions. EVC001 helps guide immune systems toward proper function.
Inflammation is a root cause of NEC, autoimmune, and allergic disease. EVC001 helps control inflammation.
Approximately 1,000 babies die per year from NEC. However, at Oregon Health State University, EVC001 reduced the risk of NEC and NEC-related deaths.
As we transform from Evolve Biosystems to Infinant Health, our vision for the future is what inspired our new name. A combination of the words “infant” and “infinite,” Infinant Health captures the start and scale of our vision, and its long-term impacts on all human health.
Our change in name also marks our strategic shift to becoming a healthcare company. We accomplish this by delivering EVC001 as standard of care at birth, along with a product portfolio of specialized and medical foods, drug pathways, and digital health medical devices to optimize infants' cognition, development, and immunity.
With the help of technologies such as metagenomics, bioinformatics, machine learning, and precision medicine, we accelerate discoveries of how nature intended for us to thrive to continue building the portfolio of products and solutions that will mitigate the health challenges of the modern world.
ACCELERATING OUR VISION, TOGETHER. A WORLD WITHOUT CHRONIC DISEASE.
We are proud to announce our global strategic partnership with the Connected World Without Disease Accelerator (CWWDA) to further our vision of a world free from chronic disease. Together, CWWDA and Infinant Health will demonstrate the power of promoting health care from birth, rather than disease care later.Read the press release for more details
We are excited about the path forward and fortunate to partner with such global health leaders as Johnson & Johnson, the Hemsley Foundation, and Kings College London.
40,000+ babies fed
When fed Evivo, inflammation is significantly reduced and potential pathogenic bacteria are suppressed, to help mitigate potentially life-threatening situations for babies in the NICU. Safe for and well tolerated by preterm babies, our Evivo MCT oil is given once a day through an NG/OG feeding tube.
B. infantis EVC001 improves the efficiency and effectiveness of a baby’s feeding time by synergizing with the HMOs in human milk to generate crucial metabolites that fuel healthy immune development. Finely milled with the naturally occurring lactose in human milk, Evivo is given once a day by mouth, from birth through the transition away from human milk.
As with adults, infants’ gut bacteria are less diverse than ever, which may play a role in disease progression later in life. C-sections and antibiotics may be partly to blame.
The healthy infant gut is an ecosystem much like a healthy ocean, and it's filled with trillions of microscopic bacteria. When environmental factors interfere with the natural balance — just as pollution does in the sea — this impacts the body’s ability to function at its best…
There’s one big problem, though: The bacteria has largely disappeared in American babies.
The labs of Evolve BioSystems are full of baby poop. Tucked into a shopping mall in Davis, California, alongside a Jazzercise and a marijuana dispensary, this biotech company has gathered infants’ feces from all over the country. “Millions of people every day are throwing away poopy diapers, and they don’t realize how much information is actually contained in each poop,” says Robin Flannery, Evolve’s director of clinical…
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Scientists note that the array of bacteria inside the gut of infants is becoming less diverse, especially in developed countries, such as the U.S., where cesarean section deliveries are on the rise. One bacterium, Bifidobacterium longum…
When Melisa Martinez's son, Juelz, was born very prematurely at25 weeks back in January, doctors at University of California, Davis Children's Hospital gave him probiotics. "They told me the probiotics may help reduce the risk of infection," Martinez says. Now, Juelz is home and doing well.
Probiotics are just one element of the care Juelz received during the weeks he spent in the NICU, but research shows that probiotics — which contain a mix of live, beneficial bacteria — can help…
We may be missing the key to one of the biggest boons to public health since the introduction of iodine into the food supply in 1924.
Scientists at the University of California, Davis, have found that a strain of bacteria called B. infantis that is thought to have been the dominant bacterium in the infant gut for all of human history is disappearing from the Western world. According to their research, this was probably caused by the rise in cesarean…
Yes, "poop happens." And while it might be embarrassing for some moms, there's a very good reason for it.
When Nancy Redd was pregnant with her first child, her birth coach dropped some truth abut labor's dirty secret.
"She said, 'You need to listen to (me) and listen good. You are going to feel like you need to poop, and you are going to poop ... Just relax and act like you are on the can and you'll be fine,'"...
1 Bajorek et al. B. infantis EVC001 Is Well-Tolerated and Improves Human Milk Oligosaccharide Utilization in Preterm Infants in the Neonatal Intensive Care Unit (2022) Frontiers in Pediatrics 9:795970
2 Frese, S. A. et al. Persistence of supplemented Bifidobacterium longum subsp. infantis EVC001 in breastfed infants. mSphere 2, e00501–17–15 (2017).
3 Nguyen, M. et al. Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation. Frontiers in Pediatrics, 9 (618009) (2021)
4 Casaburi, G. & Frese, S. Colonization of breastfed infants by Bifidobacterium longum subsp. infantis EVC001 reduces virulence gene abundance. Human Microbiome Journal 9, 7–10 (2018).
5 Henrick, B. et al. Bifidobacteria-mediated immune system imprinting early in life . Cell, 184, 1-15 (2021)
6 Henrick, B. et al. Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants. Pediatric Research 1–9 (2019).
7 Huda, M. et al. Bifidobacterium abundance in early infancy and vaccine response at 2 years of age. Pediatrics 143 (2) e20181489 (2019)